2879330-24-0
Chemical Structure
Menin-MLL-IN-32
- CAS No.: 2879330-24-0
- Formula:C32H42FN5O2
- Molecular Weight:547.71
IUPAC Name: (R)-2-(3-((1-((1-acetylpiperidin-4-yl)methyl)pyrrolidin-3-yl)methyl)-4-methyl-1H-pyrrolo[2,3-c]pyridin-1-yl)-5-fluoro-N-isopropyl-N-methylbenzamide
InChIKey: SDYMPASAZOCFDR-VWLOTQADSA-N
SMILES: CC(C)N(C)C(C1=C(C=CC(F)=C1)N2C3=CN=CC(C)=C3C(C[C@H]4CN(CC4)CC5CCN(CC5)C(C)=O)=C2)=O
Biological Activity: Menin-MLL-IN-32 (compound 51) is a Menin-MLL interaction inhibitor with an IC50 of 0.042 nM in HTRF assay. Menin-MLL-IN-32 inhibits MEIS1 mRNA expression with an IC50 of 11 nM. Menin-MLL-IN-32 shows anti-proliferative effects, with IC50 values of 8 nM, 24 nM and 1900 nM for MOLM14 cells, OCI-AML3 cells and KO-52 cells, respectively. Menin-MLL-IN-32 can be used for the study of leukemia[1].
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Menin-MLL-IN-32 | Menin-MLL-IN-32 (compound 51) is a Menin-MLL interaction inhibitor with an IC50 of 0.042 nM in HTRF assay. Menin-MLL-IN-32 inhibits MEIS1 mRNA expression with an IC50 of 11 nM. Menin-MLL-IN-32 shows anti-proliferative effects, with IC50 values of 8 nM, 24 nM and 1900 nM for MOLM14 cells, OCI-AML3 cells and KO-52 cells, respectively. Menin-MLL-IN-32 can be used for the study of leukemia. | |||||||||||||||||||||
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Keywords
