2883627-56-1
Chemical Structure
α-Synuclein-IN-24
- CAS No.: 2883627-56-1
- Formula:C22H17FN2O4
- Molecular Weight:392.38
InChIKey: XXYSCSFZDSRAII-SWGQDTFXSA-N
SMILES: OC(C=C1/C=C/C(NC(C=C2)=CC=C2NC(C3=CC=C(C=C3)F)=O)=O)=C(C=C1)O
Biological Activity: α-Synuclein-IN-24 is an α-synuclein (α-Syn) aggregation inhibitor with an IC50 of 4.0 μM. α-Synuclein-IN-24 stabilizes the secondary conformation of α-synuclein monomers, inhibits β-sheet formation, reduces oligonucleation during the aggregation lag phase, dissociates preformed aggregates, and blocks reaggregation. α-Synuclein-IN-24 reduces α-synuclein inclusions in neuronal cells and scavenges ROS. α-Synuclein-IN-24 can be used for the research of Parkinson's disease[1].
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α-Synuclein-IN-24 | α-Synuclein-IN-24 is an α-synuclein (α-Syn) aggregation inhibitor with an IC50 of 4.0 μM. α-Synuclein-IN-24 stabilizes the secondary conformation of α-synuclein monomers, inhibits β-sheet formation, reduces oligonucleation during the aggregation lag phase, dissociates preformed aggregates, and blocks reaggregation. α-Synuclein-IN-24 reduces α-synuclein inclusions in neuronal cells and scavenges ROS. α-Synuclein-IN-24 can be used for the research of Parkinson's disease. | |||||||||||||||||||||
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Keywords
