2883627-67-4
Chemical Structure
α-Synuclein-IN-20
- CAS No.: 2883627-67-4
- Formula:C22H14F2N2O4
- Molecular Weight:408.35
IUPAC Name: (E)-N-(4-(3-(3,6-dioxocyclohexa-1,4-dien-1-yl)acrylamido)phenyl)-2,4-difluorobenzamide
InChIKey: GCQWOKCZLKUXNO-BCTAIJSYSA-N
SMILES: O=C(C1=C(C=C(C=C1)F)F)NC2=CC=C(C=C2)NC(/C=C/C(C(C=C3)=O)=CC3=O)=O
Biological Activity: α-Synuclein-IN-20 is an inhibitor of α-synuclein (α-Synuclein) with an IC50 of 4.1 μM against human α-Syn. α-Synuclein-IN-20 exerts anti-aggregation effects by stabilizing the native conformation of α-Syn, inhibiting the formation of β-sheet aggregates and inclusion bodies, and dissociating mature fibrils into functional monomers. α-Synuclein-IN-20 scavenges ROS, protects and repairs dopaminergic neurons, ameliorates Parkinson's disease-like symptoms, and shows low cytotoxicity. α-Synuclein-IN-20 can be used for research related to Parkinson's disease[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
α-Synuclein-IN-20 | α-Synuclein-IN-20 is an inhibitor of α-synuclein (α-Synuclein) with an IC50 of 4.1 μM against human α-Syn. α-Synuclein-IN-20 exerts anti-aggregation effects by stabilizing the native conformation of α-Syn, inhibiting the formation of β-sheet aggregates and inclusion bodies, and dissociating mature fibrils into functional monomers. α-Synuclein-IN-20 scavenges ROS, protects and repairs dopaminergic neurons, ameliorates Parkinson's disease-like symptoms, and shows low cytotoxicity. α-Synuclein-IN-20 can be used for research related to Parkinson's disease. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
