2894793-37-2
Chemical Structure
Dopamine D3 receptor antagonist-3
- CAS No.: 2894793-37-2
- Formula:C18H17ClF5N3O3S
- Molecular Weight:485.86
IUPAC Name: N-(3-chloro-4-(trifluoromethyl)phenyl)-4-(3,3-difluoropyrrolidine-1-carbonyl)-2,5-dimethyl-1H-pyrrole-3-sulfonamide
InChIKey: VOQYONQYKMGUEP-UHFFFAOYSA-N
SMILES: ClC(C=C1NS(C(C(C(N(C2)CCC2(F)F)=O)=C3C)=C(N3)C)(=O)=O)=C(C=C1)C(F)(F)F
Biological Activity: Dopamine D3 receptor antagonist-3 is a D3 dopamine receptor (D3R)-selective positive allosteric modulator (PAM)-antagonist that can cross the blood-brain barrier. Dopamine D3 receptor antagonist-3 exhibits antagonist activity in the D3R-mediated β-arrestin recruitment assay with an IC50 and a Kd of 2.5 μM and 0.49 μM. amine D3 receptor antagonist-3 is also an antagonist in the D3R-mediated Go-BRET assay with an IC50 of 0.34 μM. Dopamine D3 receptor antagonist-3 can be used for the study of neuropsychiatric disorders, including substance use disorder[1].
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Dopamine D3 receptor antagonist-3 | Dopamine D3 receptor antagonist-3 is a D3 dopamine receptor (D3R)-selective positive allosteric modulator (PAM)-antagonist that can cross the blood-brain barrier. Dopamine D3 receptor antagonist-3 exhibits antagonist activity in the D3R-mediated β-arrestin recruitment assay with an IC50 and a Kd of 2.5 μM and 0.49 μM. amine D3 receptor antagonist-3 is also an antagonist in the D3R-mediated Go-BRET assay with an IC50 of 0.34 μM. Dopamine D3 receptor antagonist-3 can be used for the study of neuropsychiatric disorders, including substance use disorder. | |||||||||||||||||||||
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Keywords
