2897630-89-4
Chemical Structure
Antimalarial agent 19
- CAS No.: 2897630-89-4
- Formula:C22H33Cl2N5S
- Molecular Weight:470.50
IUPAC Name: N2-(tert-butyl)-N4-(3-(dimethylamino)propyl)-6-(p-tolyl)thieno[3,2-d]pyrimidine-2,4-diamine dihydrochloride
InChIKey: ZNYGZYXFJVIZLI-UHFFFAOYSA-N
SMILES: CC1=CC=C(C=C1)C2=CC3=C(C(NCCCN(C)C)=NC(NC(C)(C)C)=N3)S2.Cl.Cl
Biological Activity: Antimalarial agent 19 (compound 6e) is an antimalarial active agent. Antimalarial agent 19 has antimalarial activity for the blood stage of P. falciparum K1 and P. berghei with EC50 values of 0.3 µM, 15.3 µM, respectively. Antimalarial agent 19 has good aqueous solubility, intestinal permeability and microsomal stability compared to gamhepathiopine[1].
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Antimalarial agent 19 | Antimalarial agent 19 (compound 6e) is an antimalarial active agent. Antimalarial agent 19 has antimalarial activity for the blood stage of P. falciparum K1 and P. berghei with EC50 values of 0.3 µM, 15.3 µM, respectively. Antimalarial agent 19 has good aqueous solubility, intestinal permeability and microsomal stability compared to gamhepathiopine. | |||||||||||||||||||||
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Keywords
