2906174-89-6
2906174-89-6
Chemical Structure
EGFR/BRAF-IN-1
- CAS No.: 2906174-89-6
- Formula:C26H28ClN3O4
- Molecular Weight:481.97
IUPAC Name: 8-chloro-10-(ethoxymethyl)-2-(4-morpholinophenethyl)-2,3-dihydropyrazino[1,2-a]indole-1,4-dione
InChIKey: UFZGYOVIIUOGHF-UHFFFAOYSA-N
SMILES: CCOCC1=C2C(N(CC(N2C3=CC=C(C=C31)Cl)=O)CCC4=CC=C(C=C4)N5CCOCC5)=O
Biological Activity: EGFR/BRAF-IN-1 (compound 21), a 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivative, is a potent EGFR/BRAF inhibitor with an IC50 of 45 nM for BRAFV600E. EGFR/BRAF-IN-1 inhibits cancer cell proliferation (GI50=35 nM). EGFR/BRAF-IN-1 shows good antioxidant activity[1].
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EGFR/BRAF-IN-1 | EGFR/BRAF-IN-1 (compound 21), a 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivative, is a potent EGFR/BRAF inhibitor with an IC50 of 45 nM for BRAFV600E. EGFR/BRAF-IN-1 inhibits cancer cell proliferation (GI50=35 nM). EGFR/BRAF-IN-1 shows good antioxidant activity. | |||||||||||||||||||||
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References
Keywords
