2918814-96-5
2918814-96-5
Chemical Structure
AZ-PRMT5i-1
- CAS No.: 2918814-96-5
- Formula:C26H20F3N5O2
- Molecular Weight:491.46
InChIKey: BJIUKEMXFQJDBZ-SANMLTNESA-N
SMILES: O=C1N(CC2=CC3=C(C=C(F)C(N)=N3)N2)[C@@]4(CCN(CC5=CC=C(F)C=C5)C4=O)C6=C1C=C(F)C=C6
Biological Activity: AZ-PRMT5i-1 (Compound 28) is an effective and orally active MTAP-selective PRMT5 inhibitor. AZ-PRMT5i-1 also demonstrates MTA cooperativity and exhibits both in vitro and in vivo antitumor activities, and can be used to study MTAP-deficient cancers[1][2].
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AZ-PRMT5i-1 | AZ-PRMT5i-1 (Compound 28) is an effective and orally active MTAP-selective PRMT5 inhibitor. AZ-PRMT5i-1 also demonstrates MTA cooperativity and exhibits both in vitro and in vivo antitumor activities, and can be used to study MTAP-deficient cancers. | |||||||||||||||||||||
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References
- [1]. Smith JM, et al. Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity. J Med Chem. 2024 Jul 30. [Content Brief]
- [2]. Lynch J T, et al. AZ-PRMT5i-1: A potent MTAP-selective PRMT5 inhibitor with pharmacodynamic and monotherapy anti-tumor activity in MTAP-deleted tumours[J]. Cancer Research, 2023, 83(7_Supplement): 6272-6272.
Keywords
