2920182-91-6
2920182-91-6
Chemical Structure
SARS-CoV-2 3CLpro-IN-33
- CAS No.: 2920182-91-6
- Formula:C28H18ClF3N6O3
- Molecular Weight:578.93
InChIKey: YEURKSBHYBZKBT-UHFFFAOYSA-N
SMILES: CN1C=NC(CN2C(C3=C(N(C2=O)CC4=CC(F)=C(C(F)=C4)F)C=C(C5=C3OCC5)C6=CC(C#N)=CC=C6Cl)=O)=N1
Biological Activity: SARS-CoV-2 3CLpro-IN-33 (Compound 16) is an orally active SARS-CoV-2 3CL protease inhibitor, with an IC50 value of 1.5 nM. SARS-CoV-2 3CLpro-IN-33 shows excellent anti-SARS-CoV-2 viral activity in the HEK293T-AT cell model with an EC50 of 0.017 μM. SARS-CoV-2 3CLpro-IN-33 can be used for the study of COVID-19 infetction[1].
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SARS-CoV-2 3CLpro-IN-33 | SARS-CoV-2 3CLpro-IN-33 (Compound 16) is an orally active SARS-CoV-2 3CL protease inhibitor, with an IC50 value of 1.5 nM. SARS-CoV-2 3CLpro-IN-33 shows excellent anti-SARS-CoV-2 viral activity in the HEK293T-AT cell model with an EC50 of 0.017 μM. SARS-CoV-2 3CLpro-IN-33 can be used for the study of COVID-19 infetction. | |||||||||||||||||||||
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References
Keywords
