SARS-CoV-2 3CLpro-IN-33
SARS-CoV-2 3CLpro-IN-33 (Compound 16) is an orally active SARS-CoV-2 3CL protease inhibitor, with an IC50 value of 1.5 nM. SARS-CoV-2 3CLpro-IN-33 shows excellent anti-SARS-CoV-2 viral activity in the HEK293T-AT cell model with an EC50 of 0.017 μM. SARS-CoV-2 3CLpro-IN-33 can be used for the study of COVID-19 infetction.
For research use only. We do not sell to patients.
- CAS No.: 2920182-91-6
- Formula: C28H18ClF3N6O3
- Molecular Weight:578.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Chemical Information
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CAS No. 2920182-91-6
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Molecular Weight 578.93
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Formula C28H18ClF3N6O3
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SMILES
CN1C=NC(CN2C(C3=C(N(C2=O)CC4=CC(F)=C(C(F)=C4)F)C=C(C5=C3OCC5)C6=CC(C#N)=CC=C6Cl)=O)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)