2957888-70-7
Chemical Structure
IHCH-7086
- CAS. Nr.: 2957888-70-7
- Formula:C24H31N3O
- Molecular Weight:377.52
InChIKey: WFYFRJAKNJVZMP-SFTDATJTSA-N
SMILES: CN1C2=C3C([C@@]4([H])[C@@](CCN(C4)CCCC5=C(C=CC=C5)OC)([H])N3CC1)=CC=C2
Biological Activity: IHCH-7086 is a blood-brain barrier-permeable, partial β-arrestin-biased agonist of 5-HT2AR with a Ki of 12.59 nM. IHCH-7086 blocks D-lysergic acid diethylamide-induced head-twitch response in mice and alleviates depression-like behaviors in mice subjected to acute restraint stress or injected with Corticosterone (HY-B1618). IHCH-7086 is applicable to research related to depression[1][2].
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IHCH-7086 | 98.96% | IHCH-7086 is a blood-brain barrier-permeable, partial β-arrestin-biased agonist of 5-HT2AR with a Ki of 12.59 nM. IHCH-7086 blocks D-lysergic acid diethylamide-induced head-twitch response in mice and alleviates depression-like behaviors in mice subjected to acute restraint stress or injected with Corticosterone (HY-B1618). IHCH-7086 is applicable to research related to depression. | ||||||||||||||||||||
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- [1]. Yin YN, et al. Non-hallucinogenic Psychedelic Analog Design: A Promising Direction for Depression Treatment. Neurosci Bull. 2023 Jan;39(1):170-172. [Content Brief]
- [2]. Cao D, et al. Structure-based discovery of nonhallucinogenic psychedelic analogs. Science. 2022;375(6579):403-411. [Content Brief]
Keywords
