2965316-77-0
Chemical Structure
UCUF-965
- CAS No.: 2965316-77-0
- Formula:C22H23N5OS
- Molecular Weight:405.52
IUPAC Name: 3-(2-ethoxyphenyl)-6-(4-(pyrrolidin-1-yl)phenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
InChIKey: KMJTXMIDBWRMDF-UHFFFAOYSA-N
SMILES: N=1N=C(C=2C=CC=CC2OCC)N3N=C(C=4C=CC(=CC4)N5CCCC5)CSC13
Biological Activity: UCUF-965 is a CXCR4 positive allosteric modulator. UCUF-965 potentiates CXCL12-induced β-arrestin recruitment and cAMP signaling, activates lymphoblast migration, induces calcium flux, and does not bind CXCR4’s orthosteric CXCL12 site. UCUF-965 reduces miR-15b and miR-29a levels, increases miR-146a levels in fibroblasts. UCUF-965 enhances angiogenesis and reduces wound healing time in diabetic mice. UCUF-965 can be used for the research of diabetic wound healing impairment[1].
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UCUF-965 | UCUF-965 is a CXCR4 positive allosteric modulator. UCUF-965 potentiates CXCL12-induced β-arrestin recruitment and cAMP signaling, activates lymphoblast migration, induces calcium flux, and does not bind CXCR4’s orthosteric CXCL12 site. UCUF-965 reduces miR-15b and miR-29a levels, increases miR-146a levels in fibroblasts. UCUF-965 enhances angiogenesis and reduces wound healing time in diabetic mice. UCUF-965 can be used for the research of diabetic wound healing impairment. | |||||||||||||||||||||
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Keywords
