2986573-09-3
2986573-09-3
Chemical Structure
HIV-1 protease-IN-15
- CAS No.: 2986573-09-3
- Formula:C27H36F3N3O4S
- Molecular Weight:555.65
SMILES: O=C(N[C@@H](CC1=CC=CC=C1)[C@H](O)CN(CC(C)C)S(C2=CC=C(C(F)(F)F)C=C2)(=O)=O)[C@@H]3CCCNC3
Biological Activity: HIV-1 protease-IN-15 (Compound 27) is an orally active and selective inhibitor targeting HIV-1 protease with a pIC50 value of 9.347. HIV-1 protease-IN-15 inhibits HIV protein maturation, blocks viral replication. HIV-1 protease-IN-15 is promising for research of HIV-1 infection[1].
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HIV-1 protease-IN-15 | HIV-1 protease-IN-15 (Compound 27) is an orally active and selective inhibitor targeting HIV-1 protease with a pIC50 value of 9.347. HIV-1 protease-IN-15 inhibits HIV protein maturation, blocks viral replication. HIV-1 protease-IN-15 is promising for research of HIV-1 infection. | |||||||||||||||||||||
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References
- [1]. Chen J, et al. Rational Design and Multi-tiered Computational Evaluation of Novel Darunavir Derivatives as HIV-1 Protease Inhibitors: an Integrated Approach Using QSAR Model, Molecular Docking, MD Simulations, DFT Analysis, and ADME Profiling. Chem Biodivers. 2025 May 30:e03500. [Content Brief]
Keywords
