299901-57-8
299901-57-8
Chemical Structure
Desmethyl-YM-298198
- CAS No.: 299901-57-8
- Formula:C17H20N4OS
- Molecular Weight:328.43
IUPAC Name: 6-amino-N-cyclohexyl-3-methylbenzo[4,5]imidazo[2,1-b]thiazole-2-carboxamide
InChIKey: VWOMTTIMBHBPBI-UHFFFAOYSA-N
SMILES: O=C(C1=C(C)N2C3=CC(N)=CC=C3N=C2S1)NC4CCCCC4
Biological Activity: Desmethyl-YM-298198 is a high-affinity, selective, and noncompetitive mGluR1 antagonist (IC50: 16 nM). Desmethyl-YM-298198 has analgesic effect in Streptozotocin (HY-13753)-induced hyperalgesic mice[1].
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Desmethyl-YM-298198 | Desmethyl-YM-298198 is a high-affinity, selective, and noncompetitive mGluR1 antagonist (IC50: 16 nM). Desmethyl-YM-298198 has analgesic effect in Streptozotocin (HY-13753)-induced hyperalgesic mice. | |||||||||||||||||||||
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References
- [1]. Kohara A, et al. Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor type 1. J Pharmacol Exp Ther. 2005 Oct;315(1):163-9. [Content Brief]
Keywords
