3008543-34-5
Chemical Structure
EGFR/AURKB-IN-1
- CAS No.: 3008543-34-5
- Formula:C23H20N6O
- Molecular Weight:396.44
InChIKey: XIVMLVCBASNGOD-UHFFFAOYSA-N
SMILES: CN1N=CC=C1C2=CC3=C(N=CN=C3N2)NC4=CC=C(C=C4)OCC5=CC=CC=C5
Biological Activity: EGFR/AURKB-IN-1 (compound 7) is a dual-targeted EGFR/AURKB inhibitor, and inhibits the phpsphorylations of L858R EGFR and AURKB with IC50s of 0.07 and 1.1, respectively. EGFR/AURKB-IN-1 occupies the hydrophobic region I or the αC-helix out pocket of EGFR and the back pocket of AURKB, inhibiting the growth, division and metastasis of tumor cells, thus can be used for cancer research[1].
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EGFR/AURKB-IN-1 | 99.43% | EGFR/AURKB-IN-1 (compound 7) is a dual-targeted EGFR/AURKB inhibitor, and inhibits the phpsphorylations of L858R EGFR and AURKB with IC50s of 0.07 and 1.1, respectively. EGFR/AURKB-IN-1 occupies the hydrophobic region I or the αC-helix out pocket of EGFR and the back pocket of AURKB, inhibiting the growth, division and metastasis of tumor cells, thus can be used for cancer research. | ||||||||||||||||||||
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Keywords
