2. JAK/STAT Signaling Epigenetics Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK
  3. EGFR Aurora Kinase
  4. EGFR/AURKB-IN-1

EGFR/AURKB-IN-1 (compound 7) is a dual-targeted EGFR/AURKB inhibitor, and inhibits the phpsphorylations of L858R EGFR and AURKB with IC50s of 0.07 and 1.1, respectively. EGFR/AURKB-IN-1 occupies the hydrophobic region I or the αC-helix out pocket of EGFR and the back pocket of AURKB, inhibiting the growth, division and metastasis of tumor cells, thus can be used for cancer research.

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EGFR/AURKB-IN-1 Chemical Structure

EGFR/AURKB-IN-1 Chemical Structure

CAS No. : 3008543-34-5

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EGFR/AURKB-IN-1 Related Antibodies

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Description

EGFR/AURKB-IN-1 (compound 7) is a dual-targeted EGFR/AURKB inhibitor, and inhibits the phpsphorylations of L858R EGFR and AURKB with IC50s of 0.07 and 1.1, respectively. EGFR/AURKB-IN-1 occupies the hydrophobic region I or the αC-helix out pocket of EGFR and the back pocket of AURKB, inhibiting the growth, division and metastasis of tumor cells, thus can be used for cancer research[1].

Molecular Weight

396.44

Formula

C23H20N6O
CAS No.
SMILES

CN1N=CC=C1C2=CC3=C(N=CN=C3N2)NC4=CC=C(C=C4)OCC5=CC=CC=C5
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EGFR/AURKB-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/AURKB-IN-13008543-34-5EGFRAurora KinaseEpidermal growth factor receptorErbB-1HER1NSCLCAURKBinhibitorInhibitorinhibit

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