3031349-25-1
3031349-25-1
Chemical Structure
TH-6
- CAS No.: 3031349-25-1
- Formula:C22H24FN3O5
- Molecular Weight:429.44
IUPAC Name: (E)-5-fluoro-N-(3-(3-(hydroxyamino)-3-oxoprop-1-en-1-yl)-4-methoxybenzyl)-2-morpholinobenzamide
InChIKey: ICQRPCMAJHVDPX-XVNBXDOJSA-N
SMILES: ONC(/C=C/C(C=C1CNC(C2=C(N3CCOCC3)C=CC(F)=C2)=O)=C(C=C1)OC)=O
Biological Activity: TH-6 is a potent HDAC inhibitor with IC50s of 0.115, 0.135, 0.242, 0.138, 2.120 µM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively. TH-6 inhibits cell migration and invasion. TH-6 induces apoptosis and cell cycle arrest at G2/M phase. TH-6 shows anti-tumor activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TH-6 | 95.00% | TH-6 is a potent HDAC inhibitor with IC50s of 0.115, 0.135, 0.242, 0.138, 2.120 µM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively. TH-6 inhibits cell migration and invasion. TH-6 induces apoptosis and cell cycle arrest at G2/M phase. TH-6 shows anti-tumor activity. | ||||||||||||||||||||
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References
Keywords
