3031413-08-5

HER2-IN-16 Chemical Structure
3031413-08-5

Chemical Structure

HER2-IN-16

  • CAS No.: 3031413-08-5
  • Formula:C25H23N9O2
  • Molecular Weight:481.51

InChIKey: JQKHMIDWWPNRAC-UHFFFAOYSA-N

SMILES: C=CC(NC1CN(C1)C2=C3C(NC4=CC(C)=C(C=C4)OC5=CC6=NC=NN6C=C5)=NC=NN3C=C2)=O

Biological Activity: HER2-IN-16 (Compound 14) is an inhibitor for HER2, which inhibits the Her YVMA exon 20 insertion mutation (HER2 YVMA) with an IC50 <200 nM. HER2-IN-16 inhibits proliferation of HER2 YVMA mutated BaF3 cells with an IC50 <200 nM and amliorates non-small-cell lung cancer (NSCLC)[1].

Cat. No. Product Name Purity Description Pricing
HY-163420 		HER2-IN-16 HER2-IN-16 (Compound 14) is an inhibitor for HER2, which inhibits the Her YVMA exon 20 insertion mutation (HER2 YVMA) with an IC50 <200 nM. HER2-IN-16 inhibits proliferation of HER2 YVMA mutated BaF3 cells with an IC50 <200 nM and amliorates non-small-cell lung cancer (NSCLC).
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