3031413-08-5
3031413-08-5
Chemical Structure
HER2-IN-16
- CAS No.: 3031413-08-5
- Formula:C25H23N9O2
- Molecular Weight:481.51
InChIKey: JQKHMIDWWPNRAC-UHFFFAOYSA-N
SMILES: C=CC(NC1CN(C1)C2=C3C(NC4=CC(C)=C(C=C4)OC5=CC6=NC=NN6C=C5)=NC=NN3C=C2)=O
Biological Activity: HER2-IN-16 (Compound 14) is an inhibitor for HER2, which inhibits the Her YVMA exon 20 insertion mutation (HER2 YVMA) with an IC50 <200 nM. HER2-IN-16 inhibits proliferation of HER2 YVMA mutated BaF3 cells with an IC50 <200 nM and amliorates non-small-cell lung cancer (NSCLC)[1].
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HER2-IN-16 | HER2-IN-16 (Compound 14) is an inhibitor for HER2, which inhibits the Her YVMA exon 20 insertion mutation (HER2 YVMA) with an IC50 <200 nM. HER2-IN-16 inhibits proliferation of HER2 YVMA mutated BaF3 cells with an IC50 <200 nM and amliorates non-small-cell lung cancer (NSCLC). | |||||||||||||||||||||
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