3033267-42-1
Chemical Structure
XPO1-IN-1
- CAS No.: 3033267-42-1
- Formula:C20H15F6N5O3S
- Molecular Weight:519.42
IUPAC Name: (1-chloroisoquinolin-6-yl)methanol
InChIKey: WULLCOQWAPGBSM-CXUHLZMHSA-N
SMILES: CS(=O)(NC1=CC=C(C=C1)/C(C(N)=O)=C\N2C=NC(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=N2)=O
Biological Activity: XPO1-IN-1 (compound D4) is an orally active and potent XPO1 inhibitor, with an IC50 of 24 nM in MM.1S cell. XPO1-IN-1 can efficiently induce cell apoptosis and cell cycle arrest. XPO1-IN-1 displays favorable metabolic stability and pharmacokinetic properties. XPO1-IN-1 can be used for multiple myeloma (MM) research[1].
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XPO1-IN-1 | 98.08% | XPO1-IN-1 (compound D4) is an orally active and potent XPO1 inhibitor, with an IC50 of 24 nM in MM.1S cell. XPO1-IN-1 can efficiently induce cell apoptosis and cell cycle arrest. XPO1-IN-1 displays favorable metabolic stability and pharmacokinetic properties. XPO1-IN-1 can be used for multiple myeloma (MM) research. | ||||||||||||||||||||
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Keywords
