3033846-20-4
3033846-20-4
Chemical Structure
SIK-IN-2
- CAS No.: 3033846-20-4
- Formula:C22H22N6OS
- Molecular Weight:418.51
InChIKey: KDPXVKRYHKSBPY-UHFFFAOYSA-N
SMILES: N#CC1=C(N)C=CC2=NC=C(C3=CC(OCC4(N)CCCC4)=C(C#N)C(SC)=C3)N21
Biological Activity: SIK-IN-2 (Compound 45) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC50s of 0.1, 0.2 and 0.4 nM, respectively. SIK-IN-2 inhibits the release of TNFa with IC50 of 0.5 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC50 of 2 nM in human macrophages[1].
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SIK-IN-2 | SIK-IN-2 (Compound 45) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC50s of 0.1, 0.2 and 0.4 nM, respectively. SIK-IN-2 inhibits the release of TNFa with IC50 of 0.5 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC50 of 2 nM in human macrophages. | |||||||||||||||||||||
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References
Keywords
