3035072-48-8
3035072-48-8
Chemical Structure
RTx-152
- CAS No.: 3035072-48-8
- Formula:C20H16F7N3O3
- Molecular Weight:479.35
InChIKey: OMLNQKKHSWHSNR-UHFFFAOYSA-N
SMILES: FC(F)(F)C1=CC(N2CCN(C)C2=O)=C(OC(N(C3=CC=C(F)C=C3)C)=O)C(C(F)(F)F)=C1
Biological Activity: RTx-152 traps Polθ on DNA and is an allosteric Polθ-pol inhibitor (IC50: 6.2 nM). RTx-152 selectively kills HR-deficient cancer cells, and suppresses PARP inhibitor resistance in multiple genetic backgrounds, including homologous recombination (HR)-proficient cells. RTx-152 selectively kills BRCA2-null cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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RTx-152 | 99.71% | RTx-152 traps Polθ on DNA and is an allosteric Polθ-pol inhibitor (IC50: 6.2 nM). RTx-152 selectively kills HR-deficient cancer cells, and suppresses PARP inhibitor resistance in multiple genetic backgrounds, including homologous recombination (HR)-proficient cells. RTx-152 selectively kills BRCA2-null cells. | ||||||||||||||||||||
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