303983-00-8
Chemical Structure
JNJ-27548547
- CAS No.: 303983-00-8
- Formula:C62H98N4O11S2
- Molecular Weight:1139.59
InChIKey: LIHIIWJRSSLKKX-YCTALCSSSA-N
SMILES: CO[C@]12[C@]3([H])[C@@](CN1C4=C(C(C(N)=C(C4=O)C)=O)[C@H]2COC(N)=O)([H])N3C(OCC5=CC=C(SSCC(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)C=C5)=O
Biological Activity: JNJ-27548547, Mitomycin C (HY-13316) prodrug, is a Mitomycin C and lipophilic group conjugate. JNJ-27548547 undergoes thiolytic cleavage of its dithiobenzyl linker in the presence of reducing agents to release active substance Mitomycin C. JNJ-27548547 is formulated into pegylated liposomes (PL-MLP) with high antitumor activity in mice models[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
JNJ-27548547 | JNJ-27548547, Mitomycin C (HY-13316) prodrug, is a Mitomycin C and lipophilic group conjugate. JNJ-27548547 undergoes thiolytic cleavage of its dithiobenzyl linker in the presence of reducing agents to release active substance Mitomycin C. JNJ-27548547 is formulated into pegylated liposomes (PL-MLP) with high antitumor activity in mice models. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
