3043670-74-9
Chemical Structure
PROTAC K-Ras Degrader-2
- CAS No.: 3043670-74-9
- Formula:C52H60F4N8O5
- Molecular Weight:953.08
InChIKey: KLRWVBDLOXWJKN-SAAGSCKISA-N
SMILES: FC1=C(C2=CC(O)=CC3=C2C(CC)=C(F)C=C3)N=CC4=C1N=C(N=C4N5C[C@](O)(CCC5)C)OCC6(CC6)CN7CCC(C)(CC7)CN8CCN(C9=CC(F)=C(C%10C(NC(CC%10)=O)=O)C(F)=C9)CC8
Biological Activity: PROTAC K-Ras degrader-2 (compound 48) is a KRAS G12V PROTAC degrader with an IC50 of 20-200 nM for KRAS G12V/RAF1. PROTAC K-Ras degrader-2 degrades SW620 KRAS G12V with a DC50 of 1-10 nM. PROTAC K-Ras degrader-2 inhibits cell growth of SW620 3D cell with an IC50 of ≤10 nM. PROTAC K-Ras degrader-2 can be used for the study of colorectal cancer (CRC)[1].
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PROTAC K-Ras Degrader-2 | PROTAC K-Ras degrader-2 (compound 48) is a KRAS G12V PROTAC degrader with an IC50 of 20-200 nM for KRAS G12V/RAF1. PROTAC K-Ras degrader-2 degrades SW620 KRAS G12V with a DC50 of 1-10 nM. PROTAC K-Ras degrader-2 inhibits cell growth of SW620 3D cell with an IC50 of ≤10 nM. PROTAC K-Ras degrader-2 can be used for the study of colorectal cancer (CRC). | |||||||||||||||||||||
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Keywords
