3054263-27-0
3054263-27-0
Chemical Structure
EGFR-IN-141
- CAS No.: 3054263-27-0
- Formula:C20H15FN8O2S2
- Molecular Weight:482.51
InChIKey: BFTUGHVJFUMINZ-UHFFFAOYSA-N
SMILES: O=C1C2=C(N=CN1CC3=NN=C(N3N)SCC(NC4=NC5=C(S4)C=C(F)C=C5)=O)C=CC=C2
Biological Activity: EGFR-IN-141 (Compound 8I) is the inhibitor for EGFR with an IC50 of 2.67 nM. EGFR-IN-141 exhibits cytotoxicity in cancer cell A549 with an IC50 of 13.75 μM. EGFR-IN-141 induces apoptosis and mitochondrial membrane depolarization, and exhibits potential antitumor efficacy[1].
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EGFR-IN-141 | EGFR-IN-141 (Compound 8I) is the inhibitor for EGFR with an IC50 of 2.67 nM. EGFR-IN-141 exhibits cytotoxicity in cancer cell A549 with an IC50 of 13.75 μM. EGFR-IN-141 induces apoptosis and mitochondrial membrane depolarization, and exhibits potential antitumor efficacy. | |||||||||||||||||||||
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References
Keywords
