3054869-29-0
3054869-29-0
Chemical Structure
BET-IN-27
- CAS. Nr.: 3054869-29-0
- Formula:C21H23N5O3S
- Molecular Weight:425.50
SMILES: CN(C(C1=C2C=CN1)=O)C=C2C3=NC4=C(SC(C(C)(C)O)=C4)C(N5CCOCC5)=N3
Biological Activity: BET-IN-27 (compound 6C) is an oral BET inhibitor with the IC50 values of 3.3 nM (BRD4-BD2)、3.4 nM (BRD4-BD1)、4.1 nM (BRD2-BD1)、20.4 nM (BRD3-BD1) and 42.0 nM (BRDT-BD1), respectively. BET-IN-27 shows anti-proliferative activity[1].
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BET-IN-27 | BET-IN-27 (compound 6C) is an oral BET inhibitor with the IC50 values of 3.3 nM (BRD4-BD2)、3.4 nM (BRD4-BD1)、4.1 nM (BRD2-BD1)、20.4 nM (BRD3-BD1) and 42.0 nM (BRDT-BD1), respectively. BET-IN-27 shows anti-proliferative activity. | |||||||||||||||||||||
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References
Keywords
