3064450-12-7
3064450-12-7
Chemical Structure
EGFR-IN-136
- CAS No.: 3064450-12-7
- Formula:C30H36N7O4P
- Molecular Weight:589.63
InChIKey: HGSJQOUQNLIDFP-UHFFFAOYSA-N
SMILES: COC1=CC(N2CCOCC2)=C(C3=CN4N=C3)C=C1NC5=NC(NC6=CC=C(OCCC4)C=C6P(C)(C)=O)=C(C)C=N5
Biological Activity: EGFR-IN-136 (compound 21v) is a potent EGFR inhibitor with IC50 values of 20.2, 1.2, 2.3, 12.5 nM for EGFRWT, EGFRLR/TM, EGFR19D/TM/CS, EGFRLR/TM/CS, respectively. EGFR-IN-136 shows antiproliferative activity. EGFR-IN-136 shows antitumor activity and has the potential for the research of NSCLC[1].
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EGFR-IN-136 | EGFR-IN-136 (compound 21v) is a potent EGFR inhibitor with IC50 values of 20.2, 1.2, 2.3, 12.5 nM for EGFRWT, EGFRLR/TM, EGFR19D/TM/CS, EGFRLR/TM/CS, respectively. EGFR-IN-136 shows antiproliferative activity. EGFR-IN-136 shows antitumor activity and has the potential for the research of NSCLC. | |||||||||||||||||||||
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References
Keywords
