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Cat. No.: HY-169982

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EGFR-IN-136

EGFR-IN-136 (compound 21v) is a potent EGFR inhibitor with IC₅₀ values of 20.2, 1.2, 2.3, 12.5 nM for EGFR^WT, EGFR^LR/TM, EGFR^19D/TM/CS, EGFR^LR/TM/CS, respectively. EGFR-IN-136 shows antiproliferative activity. EGFR-IN-136 shows antitumor activity and has the potential for the research of NSCLC.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3064450-12-7
화학식: C₃₀H₃₆N₇O₄P
분자량:589.63

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

EGFR-IN-136 Chemical Structure

CAS No.: 3064450-12-7

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

EGFR (WT)

20.2 nM (IC₅₀)

EGFR^LR/TM

1.2 nM (IC₅₀)

EGFR^19del/TM/CS

2.3 nM (IC₅₀)

EGFR^LR/TM/CS

2.5 nM (IC₅₀)

All EGFR Isoforms :

Chemical Information

CAS No. 3064450-12-7
분자량 589.63
화학식 C₃₀H₃₆N₇O₄P
SMILES

COC1=CC(N2CCOCC2)=C(C3=CN4N=C3)C=C1NC5=NC(NC6=CC=C(OCCC4)C=C6P(C)(C)=O)=C(C)C=N5
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hu S, et al. Design, Synthesis, and Biological Evaluation of Novel Diaminopyrimidine Macrocycles as Fourth Generation Reversible EGFR Inhibitors That Overcome Clinical Resistance to Osimertinib Mediated by C797S Mutation. J Med Chem. 2024 Nov 28;67(22):20531-20558. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

EGFR-IN-136

All EGFR Isoforms

Biological Activity

제품 설명

IC50 & Target

Chemical Information

순도&문서

References

Calculators

Help & FAQs

EGFR-IN-136 Related Classifications

HY-169982 Related Classifications

Bioz

Keywords

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