EGFR-IN-136
EGFR-IN-136 (compound 21v) is a potent EGFR inhibitor with IC50 values of 20.2, 1.2, 2.3, 12.5 nM for EGFRWT, EGFRLR/TM, EGFR19D/TM/CS, EGFRLR/TM/CS, respectively. EGFR-IN-136 shows antiproliferative activity. EGFR-IN-136 shows antitumor activity and has the potential for the research of NSCLC.
For research use only. We do not sell to patients.
- CAS No.: 3064450-12-7
- Formula: C30H36N7O4P
- Molecular Weight:589.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All EGFR Isoforms
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Biological Activity
|
EGFR (WT) 20.2 nM (IC50) |
EGFRLR/TM 1.2 nM (IC50) |
EGFR19del/TM/CS 2.3 nM (IC50) |
EGFRLR/TM/CS 2.5 nM (IC50) |
Chemical Information
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CAS No. 3064450-12-7
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Molecular Weight 589.63
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Formula C30H36N7O4P
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SMILES
COC1=CC(N2CCOCC2)=C(C3=CN4N=C3)C=C1NC5=NC(NC6=CC=C(OCCC4)C=C6P(C)(C)=O)=C(C)C=N5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)