3068378-38-8
3068378-38-8
Chemical Structure
GSK3β-IN-2
- CAS No.: 3068378-38-8
- Formula:C25H18N4O
- Molecular Weight:390.44
InChIKey: AZROWJKGAIMYRD-UHFFFAOYSA-N
SMILES: O=C(C1=CNC2=NC=C(C3=CC=CC=C3)C=C21)NC4=C(C5=CC=CC=C5)C=CN=C4
Biological Activity: GSK3β-IN-2 (Compound S01) is the inhibitor for GSK3β with an IC50 of 0.35 nM. GSK3β-IN-2 activates Wnt/β-catenin signaling pathway, promotes neurogenesis and neurite growth. GSK3β-IN-2 inhibits Aβ-induced tau hyperphosphorylation at Ser396, reduces the formation of neurofibrillary tangles. GSK3β-IN-2 ameliorates Alzheimer's Disease in zebrafish model[1].
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GSK3β-IN-2 | 98.75% | GSK3β-IN-2 (Compound S01) is the inhibitor for GSK3β with an IC50 of 0.35 nM. GSK3β-IN-2 activates Wnt/β-catenin signaling pathway, promotes neurogenesis and neurite growth. GSK3β-IN-2 inhibits Aβ-induced tau hyperphosphorylation at Ser396, reduces the formation of neurofibrillary tangles. GSK3β-IN-2 ameliorates Alzheimer's Disease in zebrafish model. | ||||||||||||||||||||
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References
Keywords
