3085516-79-3
3085516-79-3
Chemical Structure
KRAS G12C-IN-74
- CAS No.: 3085516-79-3
- Formula:C33H38FN7O2S
- Molecular Weight:615.76
InChIKey: WDVHKLADCRYNLR-DEOSSOPVSA-N
SMILES: O=C(N1[C@H](CN(C2=NC(OCC34N(CCC4)CCC3)=NC5=C2CCN(C5)C6=CC=CC7=C6C(C)=CS7)CC1)CC#N)C(F)=C
Biological Activity: KRAS G12C-IN-74 is an orally active, selective KRASG12C inhibitor with a target IC50 of 43.18 nM. KRAS G12C-IN-74 induces G0/G1 cell cycle arrest and apoptosis in KRASG12C-mutant cancer cells. KRAS G12C-IN-74 is applicable for the research of KRASG12C-mutant pancreatic cancer, colorectal cancer and lung cancer[1].
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KRAS G12C-IN-74 | KRAS G12C-IN-74 is an orally active, selective KRASG12C inhibitor with a target IC50 of 43.18 nM. KRAS G12C-IN-74 induces G0/G1 cell cycle arrest and apoptosis in KRASG12C-mutant cancer cells. KRAS G12C-IN-74 is applicable for the research of KRASG12C-mutant pancreatic cancer, colorectal cancer and lung cancer. | |||||||||||||||||||||
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References
Keywords
