3105281-39-5
Chemical Structure
RNA binder 1
- CAS No.: 3105281-39-5
- Formula:C22H20N10S2
- Molecular Weight:488.59
InChIKey: BLYYVOBYSNDSJB-NXMZODBASA-N
SMILES: NC(N/N=C/C1=CC=CC(C2=CC=C(S2)C3=CC=C(S3)C4=CC=CC(/C=N/NC(N)=N)=N4)=N1)=N
Biological Activity: RNA binder 1 (Compound 4b) is a blood-brain permeable RNA binder. RNA binder 1 can selectively bind to the G-quadruplex structure of the G4C2 repeat sequence RNA of the C9orf72 gene. RNA binder 1 significantly reduces the levels of toxic polypeptides poly(GA) and poly(GP) produced by the G4C2 repeat sequence in amyotrophic lateral sclerosis (ALS) patient-derived cells. RNA binder 1 has no significant effect on the antisense polypeptide poly(PR), showing selectivity for sense RNA. RNA binder 1 can be used in the study of ALS and frontotemporal dementia (FTD)[1].
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RNA binder 1 | RNA binder 1 (Compound 4b) is a blood-brain permeable RNA binder. RNA binder 1 can selectively bind to the G-quadruplex structure of the G4C2 repeat sequence RNA of the C9orf72 gene. RNA binder 1 significantly reduces the levels of toxic polypeptides poly(GA) and poly(GP) produced by the G4C2 repeat sequence in amyotrophic lateral sclerosis (ALS) patient-derived cells. RNA binder 1 has no significant effect on the antisense polypeptide poly(PR), showing selectivity for sense RNA. RNA binder 1 can be used in the study of ALS and frontotemporal dementia (FTD). | |||||||||||||||||||||
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Keywords
