3122934-62-4
Chemical Structure
Antifungal agent-166
- CAS No.: 3122934-62-4
- Formula:C24H21F2N9O2S
- Molecular Weight:537.54
InChIKey: YXOVLSSVYUGUDB-UHFFFAOYSA-N
SMILES: S=C(NNC1=NC(NCC2=CC=C(F)C=C2)=NC(NCC3=CC=C(F)C=C3)=N1)NC4=CC=C([N+]([O-])=O)C=C4
Biological Activity: Antifungal agent-166 is an antifungal agent. The combination of Antifungal agent-166 and Fluconazole exerts synergistic bacteriostatic effects against fluconazole-resistant Candida albicans. Antifungal agent-166 exhibits bacteriostatic activity against both Candida glabrata and Cryptococcus neoformans. Antifungal agent-166 reverses the fluconazole resistance of strains by downregulating ergosterol synthesis-related genes, drug resistance-related genes and virulence-related genes. Antifungal agent-166 can enhance the efficacy of Fluconazole in Galleria mellonella and mouse candidiasis models, reduce fungal load and improve survival rate. Antifungal agent-166 can be used in the research of fungal infections[1].
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Antifungal agent-166 | Antifungal agent-166 is an antifungal agent. The combination of Antifungal agent-166 and Fluconazole exerts synergistic bacteriostatic effects against fluconazole-resistant Candida albicans. Antifungal agent-166 exhibits bacteriostatic activity against both Candida glabrata and Cryptococcus neoformans. Antifungal agent-166 reverses the fluconazole resistance of strains by downregulating ergosterol synthesis-related genes, drug resistance-related genes and virulence-related genes. Antifungal agent-166 can enhance the efficacy of Fluconazole in Galleria mellonella and mouse candidiasis models, reduce fungal load and improve survival rate. Antifungal agent-166 can be used in the research of fungal infections. | |||||||||||||||||||||
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Keywords
