313526-24-8
313526-24-8
Chemical Structure
IBR2
- CAS No.: 313526-24-8
- Formula:C24H20N2O2S
- Molecular Weight:400.49
IUPAC Name: 2-(benzylsulfonyl)-1-(1H-indol-3-yl)-1,2-dihydroisoquinoline
InChIKey: YCOHEPDJLXZVBZ-UHFFFAOYSA-N
SMILES: O=S(N1C(C2=CNC3=C2C=CC=C3)C4=C(C=CC=C4)C=C1)(CC5=CC=CC=C5)=O
Biological Activity: IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis[1][2].
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IBR2 | 98.24% | IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis. | ||||||||||||||||||||
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IBR2 (Standard) | ≥98% | IBR2 (Standard) is the analytical standard of IBR2 (HY-103710). This product is intended for research and analytical applications. IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51-mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis. | ||||||||||||||||||||
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References
- [1]. Jiewen Zhu, et al. A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia. EMBO Mol Med. 2013 Mar;5(3):353-65. [Content Brief]
- [2]. Zhu J, et al. Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors. Eur J Med Chem. 2015;96:196-208. [Content Brief]
Keywords
