3162-09-2
Chemical Structure
Artocarpesin
- CAS No.: 3162-09-2
- Formula:C20H18O6
- Molecular Weight:354.35
SMILES: O=C1C=C(C2=C(O)C=C(O)C=C2)OC3=CC(O)=C(C/C=C(C)\C)C(O)=C13
Biological Activity: Artocarpesin is a flavonoid compound. Artocarpesin has inhibitory effects on methicillin-resistant Staphylococcus aureus (MRSA). Artocarpesin inhibits the production of NO, PGE2 and ROS by inhibiting COX-2 and iNOS expression, and plays an anti-inflammatory role. In addition, Artocarpesin inhibits platelet aggregation by inhibiting cyclic nucleotides and MAPKs, which can be used in the study of cardiovascular diseases[1][2][3].
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Artocarpesin | Artocarpesin is a flavonoid compound. Artocarpesin has inhibitory effects on methicillin-resistant Staphylococcus aureus (MRSA). Artocarpesin inhibits the production of NO, PGE2 and ROS by inhibiting COX-2 and iNOS expression, and plays an anti-inflammatory role. In addition, Artocarpesin inhibits platelet aggregation by inhibiting cyclic nucleotides and MAPKs, which can be used in the study of cardiovascular diseases. | |||||||||||||||||||||
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- [1]. Manuel N G V, et al. Antimicrobial activity of artocarpesin from Artocarpus heterophyllus Lam. against methicillin-resistant Staphylococcus aureus (MRSA). Journal of Medicinal Plants Research, 2012, 6(34): 4879-82.
- [2]. Fang SC, et al. Anti-inflammatory effects of phenolic compounds isolated from the fruits of Artocarpus heterophyllus. J Agric Food Chem. 2008 Jun 25;56(12):4463-8. [Content Brief]
- [3]. Kwon H W, et al. Artocarpesin acts on human platelet aggregation through inhibition of cyclic nucleotides and MAPKs. Applied Biological Chemistry, 2022, 65(1): 25.
Keywords
