331443-00-6
Chemical Structure
4-Hydroxyresveratrol
Synonym(s): 3,4,5,4'-Tetrahydroxystibene
- CAS No.: 331443-00-6
- Formula:C14H12O4
- Molecular Weight:244.24
IUPAC Name: (E)-5-(4-hydroxystyryl)benzene-1,2,3-triol
InChIKey: GRZOJEWQFCAKPF-OWOJBTEDSA-N
SMILES: OC1=CC(/C=C/C2=CC=C(O)C=C2)=CC(O)=C1O
Biological Activity: 4-Hydroxyresveratrol (3,4,5,4'-Tetrahydroxystibene), a Resveratrol (HY-16561) analog, differentially induces pro-apoptotic p53/Bax gene expression. 4-Hydroxyresveratrol induces apoptosis in SV40 virally transformed WI38 cells (WI38VA) cells, but not in WI38 cells. 4-Hydroxyresveratrol significantly induces the expression of p53, GADD45 and Bax genes and concomitantly suppresses the expression of bcl-2 gene in WI38VA[1].
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4-Hydroxyresveratrol | 4-Hydroxyresveratrol (3,4,5,4'-Tetrahydroxystibene), a Resveratrol (HY-16561) analog, differentially induces pro-apoptotic p53/Bax gene expression. 4-Hydroxyresveratrol induces apoptosis in SV40 virally transformed WI38 cells (WI38VA) cells, but not in WI38 cells. 4-Hydroxyresveratrol significantly induces the expression of p53, GADD45 and Bax genes and concomitantly suppresses the expression of bcl-2 gene in WI38VA. | |||||||||||||||||||||
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Keywords
