362508-67-6
Chemical Structure
S101
- CAS No.: 362508-67-6
- Formula:C24H23N3O3
- Molecular Weight:401.47
IUPAC Name: N-(p-tolyl)-2-(3,4,5-trimethoxyphenyl)quinazolin-4-amine
InChIKey: SMRHGURAMRNJTP-UHFFFAOYSA-N
SMILES: N=1C(=NC(NC2=CC=C(C=C2)C)=C3C=CC=CC13)C=4C=C(OC)C(OC)=C(OC)C4
Biological Activity: S101 is an inhibitor of SLP-76 and AhR. By inhibiting SLP-76 phosphorylation, S101 blocks the TCR signaling pathway and prevents AhR nuclear translocation, thereby selectively suppressing the proliferation of activated T cells, inducing their apoptosis, and reducing TNF-α levels. S101 can be used in studies of graft rejection, psoriasis, and superantigen-induced toxic shock[1][2].
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S101 | S101 is an inhibitor of SLP-76 and AhR. By inhibiting SLP-76 phosphorylation, S101 blocks the TCR signaling pathway and prevents AhR nuclear translocation, thereby selectively suppressing the proliferation of activated T cells, inducing their apoptosis, and reducing TNF-α levels. S101 can be used in studies of graft rejection, psoriasis, and superantigen-induced toxic shock. | |||||||||||||||||||||
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References
- [1]. Sagiv-Barfi I, et al. Design, synthesis, and evaluation of quinazoline T cell proliferation inhibitors. Bioorganic & medicinal chemistry. 2010 Sep 01;18(17):6404-13.
- [2]. Shir A, et al. S101, an Inhibitor of Proliferating T Cells, Rescues Mice From Superantigen-Induced Shock. The Journal of infectious diseases. 2018 Jan 04;217(2):288-297.
