364076-99-3
Chemical Structure
(E/Z)-OT-R antagonist 1
- CAS No.: 364076-99-3
- Formula:C28H29N3O4
- Molecular Weight:471.55
IUPAC Name: (S,Z)-N-((S)-2-hydroxy-2-phenylethyl)-4-(methoxyimino)-1-(2'-methyl-[1,1'-biphenyl]-4-carbonyl)pyrrolidine-2-carboxamide
InChIKey: IBXGJPAYWMFXSF-UEEONYLUSA-N
SMILES: O=C([C@H](C/1)N(C(C2=CC=C(C3=C(C)C=CC=C3)C=C2)=O)CC1=N/OC)NC[C@@H](O)C4=CC=CC=C4
Biological Activity: (E/Z)-OT-R antagonist 1 is a mixture of E/Z forms of OT-R antagonist 1 (HY-15015). OT-R antagonist 1 is a novel, potent, selective non-peptide OT-R antagonist that inhibits oxytocin-induced intracellular Ca2+ activation (IC50 = 8 nM)[1][2][3][4].
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(E/Z)-OT-R antagonist 1 | (E/Z)-OT-R antagonist 1 is a mixture of E/Z forms of OT-R antagonist 1 (HY-15015). OT-R antagonist 1 is a novel, potent, selective non-peptide OT-R antagonist that inhibits oxytocin-induced intracellular Ca2+ activation (IC50 = 8 nM). | |||||||||||||||||||||
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- [1]. Serge Halazy, et al. Pharmaceutically active pyrrolidine derivatives as bax inhibitors. WO/2001072705/A1.
- [2]. Cirillo R, et al. Pharmacology of (2S,4Z)-N-[(2S)-2-hydroxy-2-phenylethyl]-4-(methoxyimino) -1-[(2'-methyl[1,1'-biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide, a new potent and selective nonpeptide antagonist of the oxytocin receptor. J Pharmacol Exp Ther. 2003 Jul;306(1):253-61. [Content Brief]
- [3]. William Nadler, et al. Method for preparing pyrrolidine oximes. WO/2005082848/A2.
- [4]. Serge Halazy, et al. Pharmaceutically active pyrrolidine derivatives as bax inhibitors.WO/2001074769/A1.
Keywords
