365276-12-6
Chemical Structure
TAK-070 hydrochloride hydrate
- CAS No.: 365276-12-6
- Formula:C27H34ClNO2
- Molecular Weight:440.02
IUPAC Name: (R)-2-(6-([1,1'-biphenyl]-4-ylmethoxy)-1,2,3,4-tetrahydronaphthalen-2-yl)-N,N-dimethylethan-1-amine hydrochloride hydrate
InChIKey: VBMPTAUGUUBFJK-FGJQBABTSA-N
SMILES: CN(C)CC[C@H]1CC2=C(C=C(OCC3=CC=C(C4=CC=CC=C4)C=C3)C=C2)CC1.Cl.O
Biological Activity: TAK-070 hydrochloride hydrate is a noncompetitive and orally active BACE1 inhibitor (IC50 = 3.15 μM). TAK-070 hydrochloride hydrate can be used for research of Alzheimer’s disease (AD). TAK-070 hydrochloride hydrate inhibits brain levels of soluble Aβ, and improves cognitive impairments in AD model[1].
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TAK-070 hydrochloride hydrate | TAK-070 hydrochloride hydrate is a noncompetitive and orally active BACE1 inhibitor (IC50 = 3.15 μM). TAK-070 hydrochloride hydrate can be used for research of Alzheimer’s disease (AD). TAK-070 hydrochloride hydrate inhibits brain levels of soluble Aβ, and improves cognitive impairments in AD model. | |||||||||||||||||||||
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Keywords
