380877-02-1
Chemical Structure
MMV667492
- CAS No.: 380877-02-1
- Formula:C17H19N3O3
- Molecular Weight:313.35
IUPAC Name: N-(3-(cyclohexylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-N-methylnitrous amide
InChIKey: QKVXPISYSQXMSA-UHFFFAOYSA-N
SMILES: O=C1C(NC2CCCCC2)=C(N(C)N=O)C(C3=C1C=CC=C3)=O
Biological Activity: MMV667492 is a potent Ezrin inhibitor with the activity to inhibit the invasion phenotype of osteosarcoma cells. MMV667492 exhibited potent anti-Ezrin activity in all biological assays and its compound properties were superior to NSC305787. MMV667492 was able to exhibit morphological defect phenotypes associated with Ezrin inhibition in zebrafish embryos. MMV667492 also showed the ability to inhibit the lung metastasis of osteosarcoma cells that highly expressed Ezrin[1].
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MMV667492 | MMV667492 is a potent Ezrin inhibitor with the activity to inhibit the invasion phenotype of osteosarcoma cells. MMV667492 exhibited potent anti-Ezrin activity in all biological assays and its compound properties were superior to NSC305787. MMV667492 was able to exhibit morphological defect phenotypes associated with Ezrin inhibition in zebrafish embryos. MMV667492 also showed the ability to inhibit the lung metastasis of osteosarcoma cells that highly expressed Ezrin. | |||||||||||||||||||||
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Keywords
