38363-32-5
38363-32-5
Chemical Structure
Penbutolol sulfate
Synonym(s): (-)-Terbuclomine
- CAS No.: 38363-32-5
- Formula:C18H29NO2 . 1/2 H2O4S
- Molecular Weight:340.47
SMILES: O[C@@H](CNC(C)(C)C)COC1=CC=CC=C1C2CCCC2.O=S(O)(O)=O
Biological Activity: Penbutolol sulfate ((-)-Terbuclomine) is a potent β-adrenoceptor and 5-HT receptor antagonist with Ki of 11.6 nM and 11.9 nM for 5-HT in rat cornu ammonis 1 (CA1) and human CA3[1][2].
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Penbutolol sulfate | 98.89% | Penbutolol sulfate ((-)-Terbuclomine) is a potent β-adrenoceptor and 5-HT receptor antagonist with Ki of 11.6 nM and 11.9 nM for 5-HT in rat cornu ammonis 1 (CA1) and human CA3. | ||||||||||||||||||||
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Penbutolol sulfate (Standard) | ≥98% | Penbutolol (sulfate) (Standard) is the analytical standard of Penbutolol (sulfate). This product is intended for research and analytical applications. Penbutolol sulfate ((-)-Terbuclomine) is a potent β-adrenoceptor and 5-HT receptor antagonist with Ki of 11.6 nM and 11.9 nM for 5-HT in rat cornu ammonis 1 (CA1) and human CA3. | ||||||||||||||||||||
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References
- [1]. Hjorth S, et al. In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-)penbutolol. J Pharmacol Exp Ther. 1993 May;265(2):707-12. [Content Brief]
- [2]. M E Castro, et al. Affinity of (±)-Pindolol, (-)-Penbutolol, and (-)-Tertatolol for Pre- and Postsynaptic Serotonin 5-HT1A Receptors in Human and Rat Brain. Journal of Neurochemistry, Volume 75, Issue 2, p. 755-762. [Content Brief]
