38620-77-8
Chemical Structure
Filipin II
- CAS No.: 38620-77-8
- Formula:C35H58O10
- Molecular Weight:638.83
IUPAC Name: (3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25E,27S,28R)-3-hexyl-4,6,8,10,12,14,16,27-octahydroxy-17,28-dimethyloxacyclooctacosa-17,19,21,23,25-pentaen-2-one
InChIKey: YMIXNQVKVPYZHL-YWSRBNGNSA-N
SMILES: O=C1O[C@H](C)[C@@H](O)/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)[C@H]1CCCCCC
Biological Activity: Filipin II is an antibiotic, which exhibits antifungal efficacy. Filipin II interacts with membrane sterols, leads to changes in membrane structure, inhibits Candida utilis and Saccharomyces cerevisiae with the MIC of 0.03 mg/L and 0.2 μg/L[1][2].
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Filipin II | Filipin II is an antibiotic, which exhibits antifungal efficacy. Filipin II interacts with membrane sterols, leads to changes in membrane structure, inhibits Candida utilis and Saccharomyces cerevisiae with the MIC of 0.03 mg/L and 0.2 μg/L. | |||||||||||||||||||||
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- [1]. Payero TD, et al., Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives. Microb Cell Fact. 2015 Aug 7;14:114. [Content Brief]
- [2]. Gao H, et al. Filipins: the first antifungal “weed killers” identified from bacteria isolated from the trap-ant[J]. Rsc Advances, 2014, 4(100): 57267-57270.
Keywords
