414858-51-8
Chemical Structure
AM-112
- CAS No.: 414858-51-8
- Formula:C14H22N2O5
- Molecular Weight:298.34
IUPAC Name: (5R,6R)-3-(5-amino-2-methylpentan-2-yl)-6-((R)-1-hydroxyethyl)-7-oxo-4-oxa-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
InChIKey: MJNFEDQKHJZAEX-RGNHYFCHSA-N
SMILES: [C@H](C)(O)[C@@]1([C@@]2(N(C(C(O)=O)=C(C(CCCN)(C)C)O2)C1=O)[H])[H]
Biological Activity: AM-112 is a β-lactamase (β-lactamase) inhibitor and antibacterial agent, with IC50 values ranging from 0.0002 μg/mL to 0.67 μg/mL against class A, C, and D β-lactamase. By inhibiting PBP2, the penicillin-binding protein of E. coli, and protecting Ceftazidime (HY-B0593) from enzymatic hydrolysis, AM-112 significantly enhances the antibacterial efficacy of Ceftazidime against Gram-negative bacteria, enterococci, and staphylococci. AM-112 exhibits favorable pharmacokinetic properties and acid-base stability. AM-112 can be used for the research of bacterial infections[1][2].
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AM-112 | AM-112 is a β-lactamase (β-lactamase) inhibitor and antibacterial agent, with IC50 values ranging from 0.0002 μg/mL to 0.67 μg/mL against class A, C, and D β-lactamase. By inhibiting PBP2, the penicillin-binding protein of E. coli, and protecting Ceftazidime (HY-B0593) from enzymatic hydrolysis, AM-112 significantly enhances the antibacterial efficacy of Ceftazidime against Gram-negative bacteria, enterococci, and staphylococci. AM-112 exhibits favorable pharmacokinetic properties and acid-base stability. AM-112 can be used for the research of bacterial infections. | |||||||||||||||||||||
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- [1]. Simpson IN, et al. Synthesis and biological activity of AM-112 and related oxapenem analogues. J Antibiot (Tokyo). 2003;56(10):838-847. [Content Brief]
- [2]. Jamieson CE, et al. In vitro activities of novel oxapenems, alone and in combination with ceftazidime, against gram-positive and gram-negative organisms. Antimicrob Agents Chemother. 2003;47(8):2615-2618. [Content Brief]
Keywords
