441785-26-8
Chemical Structure
Besifovir Dipivoxil
Synonym(s): LB-80380
- CAS No.: 441785-26-8
- Formula:C22H34N5O8P
- Molecular Weight:527.51
IUPAC Name: ((((1-((2-amino-9H-purin-9-yl)methyl)cyclopropoxy)methyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)
InChIKey: JLKJXDOWBVVABZ-UHFFFAOYSA-N
SMILES: CC(C)(C)C(OCOP(COC1(CC1)CN2C3=NC(N)=NC=C3N=C2)(OCOC(C(C)(C)C)=O)=O)=O
Biological Activity: Besifovir Dipivoxil (LB-80380), an analog of guanosine monophosphate, is an acyclic nucleotide phosphonate with antiviral effect. Besifovir Dipivoxil is rapidly converted by the liver and intestine to the intermediate metabolite LB80331 via the esterification process, subsequently phosphorylated into the di- and triphosphate forms, which act as antiviral DNA synthesis inhibitors. Besifovir Dipivoxil is promising for research of chronic hepatitis B[1].
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Besifovir Dipivoxil | Besifovir Dipivoxil (LB-80380), an analog of guanosine monophosphate, is an acyclic nucleotide phosphonate with antiviral effect. Besifovir Dipivoxil is rapidly converted by the liver and intestine to the intermediate metabolite LB80331 via the esterification process, subsequently phosphorylated into the di- and triphosphate forms, which act as antiviral DNA synthesis inhibitors. Besifovir Dipivoxil is promising for research of chronic hepatitis B. | |||||||||||||||||||||
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Keywords
