487001-04-7
487001-04-7
Chemical Structure
UC-857993
- CAS No.: 487001-04-7
- Formula:C25H22ClNO2
- Molecular Weight:403.90
IUPAC Name: 7-(2-chlorophenyl)-3b,6,6a,7,9,9a,10,12a-octahydrocyclopenta[4,5]pyrido[3,2,1-ij]cyclopenta[c]quinoline-2-carboxylic acid
InChIKey: RKRFFBBVYHOUSA-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C3N(C(C4=CC=CC=C4Cl)C5C2C=CC5)CC(CC=C6)C6C3=C1)O
Biological Activity: UC-857993 is a selective SOS1-Ras inhibitor (Kd=14.7 μM, His6-SOS1cat), suppressing catalytic activity. UC-857993 also inhibits ERK and Ras activation, suppresses the growth of mouse embryonic fibroblasts (MEFs)[1].
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UC-857993 | UC-857993 is a selective SOS1-Ras inhibitor (Kd=14.7 μM, His6-SOS1cat), suppressing catalytic activity. UC-857993 also inhibits ERK and Ras activation, suppresses the growth of mouse embryonic fibroblasts (MEFs). | |||||||||||||||||||||
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