502628-66-2
Chemical Structure
SCH-451659
Synonym(s): STX1383
- CAS No.: 502628-66-2
- Formula:C30H39Cl2N3O2
- Molecular Weight:544.56
IUPAC Name: (S)-2-(1-acetylpiperidin-4-yl)-1-(4-(bis(4-chlorophenyl)methyl)-2-(tert-butyl)piperazin-1-yl)ethan-1-one
InChIKey: AEDJOEAGMKHNID-HHHXNRCGSA-N
SMILES: CC(C)(C)[C@@H]1N(CCN(C1)C(C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)Cl)C(CC4CCN(CC4)C(C)=O)=O
Biological Activity: SCH-451659 (STX1383) is an orally active, selective 17β-HSD3 inhibitor with an IC50 of 2.4 nM against h17β-HSD3. SCH-451659 selectively blocks the conversion of androstenedione to testosterone. SCH-451659 reduces testosterone levels in mice. SCH-451659 exhibits anticancer activity against androstenedione-dependent prostate tumors[1][2].
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SCH-451659 | SCH-451659 (STX1383) is an orally active, selective 17β-HSD3 inhibitor with an IC50 of 2.4 nM against h17β-HSD3. SCH-451659 selectively blocks the conversion of androstenedione to testosterone. SCH-451659 reduces testosterone levels in mice. SCH-451659 exhibits anticancer activity against androstenedione-dependent prostate tumors. | |||||||||||||||||||||
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- [1]. Day JM, et al. STX2171, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, is efficacious in vivo in a novel hormone-dependent prostate cancer model. Endocr Relat Cancer. 2013;20(1):53-64. Published 2013 Feb 18. [Content Brief]
- [2]. Vicker N, et al. The design of novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors. Mol Cell Endocrinol. 2009;301(1-2):259-265. [Content Brief]
Keywords
