503860-57-9
503860-57-9
Chemical Structure
SAR502250
- CAS No.: 503860-57-9
- Formula:C19H18FN5O2
- Molecular Weight:367.38
IUPAC Name: (S)-2-(2-(4-fluorophenyl)morpholino)-1-methyl-[4,4'-bipyrimidin]-6(1H)-one
InChIKey: NKUNFNVAHJNALA-QGZVFWFLSA-N
SMILES: O=C1C=C(C2=NC=NC=C2)N=C(N3C[C@H](C4=CC=C(F)C=C4)OCC3)N1C
Biological Activity: SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for the research of Alzheimer’s disease (AD)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SAR502250 | 99.29% | SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for the research of Alzheimer’s disease (AD). | ||||||||||||||||||||
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References
- [1]. Fukunaga K, et, al. 2-(2-Phenylmorpholin-4-yl)pyrimidin-4(3H)-ones; a new class of potent, selective and orally active glycogen synthase kinase-3β inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6933-7. [Content Brief]
- [2]. Griebel G, et, al. The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of Alzheimer's disease in rodents. Sci Rep. 2019 Dec 2;9(1):18045. [Content Brief]
Keywords
