51867-94-8
Chemical Structure
9-Methylstreptimidone
Synonym(s): Antibiotic TS 885; NSC 248958
- CAS No.: 51867-94-8
- Formula:C17H25NO4
- Molecular Weight:307.38
IUPAC Name: 4-((2R,5S,6E,8Z)-2-hydroxy-5,7-dimethyl-4-oxodeca-6,8-dien-1-yl)piperidine-2,6-dione
InChIKey: ATUBIBZJAGAIBW-WGEALTPQSA-N
SMILES: O=C(CC(C[C@@H](O)CC([C@@H](C)/C=C(C)/C=C\C)=O)C1)NC1=O
Biological Activity: 9-Methylstreptimidone is a microbial metabolite originally isolated from Streptomyces sp. S-885 that has antifungal and antiviral activities. It is active against several fungi, including S. sake, S. fragilis, R. rubra, T. rubra, and C. albidus (MICs=4-20 μg/mL) and has antiviral activity against poliovirus, vesicular stomatitis virus (VSV), and Newcastle disease virus (NDV) in vitro (MIC=0.02 μg/mL for all). 9-Methylstreptimidone increases survival in mouse models of infection with influenza A2 (H2N2) or C. albicans when administered prior to infection.
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9-Methylstreptimidone | 9-Methylstreptimidone is a microbial metabolite originally isolated from Streptomyces sp. S-885 that has antifungal and antiviral activities. It is active against several fungi, including S. sake, S. fragilis, R. rubra, T. rubra, and C. albidus (MICs=4-20 μg/mL) and has antiviral activity against poliovirus, vesicular stomatitis virus (VSV), and Newcastle disease virus (NDV) in vitro (MIC=0.02 μg/mL for all). 9-Methylstreptimidone increases survival in mouse models of infection with influenza A2 (H2N2) or C. albicans when administered prior to infection. | |||||||||||||||||||||
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Keywords
