537-67-7
Chemical Structure
Diphenylamine hydrochloride
Synonym(s): N-Phenylaniline hydrochloride
- CAS No.: 537-67-7
- Formula:C12H12ClN
- Molecular Weight:205.69
IUPAC Name: diphenylamine hydrochloride
InChIKey: JEFJSEIUEJBMSR-UHFFFAOYSA-N
SMILES: [H]Cl.C1(NC2=CC=CC=C2)=CC=CC=C1
Biological Activity: Diphenylamine hydrochloride (N-Phenylaniline hydrochloride) is an antihyperglycemic agent with oral activity and a common structure in non-steroidal anti-inflammatory drugs (NSAIDs) that uncouples oxidative phosphorylation in mitochondria, leading to a decrease in hepatic cell ATP levels and causing liver cell damage. Diphenylamine hydrochloride is also an industrial antioxidant, a dyeing mordant, and is used in agriculture as an antifungal and antibacterial agent[1][2][3][4].
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Diphenylamine hydrochloride | 99.92% | Diphenylamine hydrochloride (N-Phenylaniline hydrochloride) is an antihyperglycemic agent with oral activity and a common structure in non-steroidal anti-inflammatory drugs (NSAIDs) that uncouples oxidative phosphorylation in mitochondria, leading to a decrease in hepatic cell ATP levels and causing liver cell damage. Diphenylamine hydrochloride is also an industrial antioxidant, a dyeing mordant, and is used in agriculture as an antifungal and antibacterial agent. | ||||||||||||||||||||
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- [1]. W E Alexander, et al. Metabolism of diphenylamine in the rat, rabbit and man. Food Cosmet Toxicol. 1965 Oct;3(4):571-9. [Content Brief]
- [2]. M S Karawya, wt al. Diphenylamine, an antihyperglycemic agent from onion and tea. J Nat Prod. 1984 Sep-Oct;47(5):775-80. [Content Brief]
- [3]. Safe S, et al. Identification of toxic impurities in commercial diphenylamine. Bull Environ Contam Toxicol. 1977 Feb;17(2):204-7. [Content Brief]
- [4]. Masubuchi Y, et al. Possible mechanism of hepatocyte injury induced by diphenylamine and its structurally related nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2000 Mar;292(3):982-7. [Content Brief]
Keywords
