55303-99-6
55303-99-6
Chemical Structure
Avarone
Synonym(s): (+)-Avarone
- CAS. Nr.: 55303-99-6
- Formula:C21H28O2
- Molecular Weight:312.45
IUPAC Name: 2-(((1R,2S,4aS,8aS)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl)methyl)cyclohexa-2,5-diene-1,4-dione
InChIKey: VPRHEJGLNUDEEH-LWILDLIXSA-N
SMILES: O=C1C(C[C@]2(C)[C@@H](C)CC[C@]3(C)C(C)=CCC[C@@]23[H])=CC(C=C1)=O
Biological Activity: Avarone ((+)-Avarone) is a sesquiterpenoidal quinone that can be isolated from Dysidea avara. Avarone shows cytotoxicity. Avarone shows antileukemic activity[1][2].
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Avarone | Avarone ((+)-Avarone) is a sesquiterpenoidal quinone that can be isolated from Dysidea avara. Avarone shows cytotoxicity. Avarone shows antileukemic activity. | |||||||||||||||||||||
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References
- [1]. Sakurai J, et al. Highly efficient total synthesis of the marine natural products (+)-avarone, (+)-avarol, (-)-neoavarone, (-)-neoavarol and (+)-aureol. Chemistry. 2008;14(3):829-37. [Content Brief]
- [2]. Müller WE, et al. Potent antileukemic activity of the novel cytostatic agent avarone and its analogues in vitro and in vivo. Cancer Res. 1985 Oct;45(10):4822-6. [Content Brief]
