56600-73-8
Chemical Structure
AKR1C2/3-IN-2
- CAS No.: 56600-73-8
- Formula:C15H16O3
- Molecular Weight:244.29
IUPAC Name: 2-(6-methoxynaphthalen-2-yl)butanoic acid
InChIKey: LSDAHSHHKKHOKE-UHFFFAOYSA-N
SMILES: O=C(C(CC)C1=CC=C2C=C(C=CC2=C1)OC)O
Biological Activity: AKR1C2/3-IN-2 is a potential AKR1C3 inhibitor with selective AKR1C3 activity. AKR1C2/3-IN-2 is able to block AKR1C3-mediated testosterone (T) production and PSA induction, affecting the endocrine activity of prostate cancer cells. AKR1C2/3-IN-2 shows selectivity over other AKR1C enzymes, indicating its potential application in inhibiting drug-resistant prostate cancer. AKR1C2/3-IN-2 has no inhibitory activity against COX isomerases, further emphasizing its specificity as a prostate cancer inhibitory compound[1].
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AKR1C2/3-IN-2 | AKR1C2/3-IN-2 is a potential AKR1C3 inhibitor with selective AKR1C3 activity. AKR1C2/3-IN-2 is able to block AKR1C3-mediated testosterone (T) production and PSA induction, affecting the endocrine activity of prostate cancer cells. AKR1C2/3-IN-2 shows selectivity over other AKR1C enzymes, indicating its potential application in inhibiting drug-resistant prostate cancer. AKR1C2/3-IN-2 has no inhibitory activity against COX isomerases, further emphasizing its specificity as a prostate cancer inhibitory compound. | |||||||||||||||||||||
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