57049-00-0
Chemical Structure
Clomiphene hydrochloride
Synonym(s): Clomifene hydrochloride; (Z/E)-Enclomiphene hydrochloride; (Z/E)-Enclomifene hydrochloride
- CAS No.: 57049-00-0
- Formula:C26H29Cl2NO
- Molecular Weight:442.42
IUPAC Name: (Z)-2-(4-(2-chloro-1,2-diphenylvinyl)phenoxy)-N,N-diethylethan-1-amine hydrochloride
InChIKey: KKBZGZWPJGOGJF-OQKDUQJOSA-N
SMILES: Cl/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(CC)CC)C=C2)/C3=CC=CC=C3.Cl
Biological Activity: Clomiphene (Clomifene; (Z/E)-Enclomiphene; (Z/E)-Enclomifene) hydrochloride is an orally active ovulation-inducing agent. Clomiphene hydrochloride binds to hypothalamic estrogen receptors to elevate FSH levels, and exhibits antiestrogenic or estrogenic properties. Clomiphene hydrochloride can induce erturbations during meiotic maturation and cytogenetic abnormalities in mouse oocytes. Clomiphene hydrochloride ameliorates memory impairment in PCOS models. Clomiphene hydrochloride mobilizes cytosolic calcium and reduces viability in prostate cancer cells. Clomiphene hydrochloride can be used for the research of polycystic ovary syndrome (PCOS) and prostate cancer[1][2][3][4].
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Clomiphene hydrochloride | Clomiphene (Clomifene; (Z/E)-Enclomiphene; (Z/E)-Enclomifene) hydrochloride is an orally active ovulation-inducing agent. Clomiphene hydrochloride binds to hypothalamic estrogen receptors to elevate FSH levels, and exhibits antiestrogenic or estrogenic properties. Clomiphene hydrochloride can induce erturbations during meiotic maturation and cytogenetic abnormalities in mouse oocytes. Clomiphene hydrochloride ameliorates memory impairment in PCOS models. Clomiphene hydrochloride mobilizes cytosolic calcium and reduces viability in prostate cancer cells. Clomiphene hydrochloride can be used for the research of polycystic ovary syndrome (PCOS) and prostate cancer. | |||||||||||||||||||||
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- [1]. London SN, et al. Clomiphene citrate-induced perturbations during meiotic maturation and cytogenetic abnormalities in mouse oocytes in vivo and in vitro. Fertil Steril. 2000;73(3):620-626. [Content Brief]
- [2]. Akintoye OO, et al. Synergistic action of carvedilol and clomiphene in mitigating the behavioral phenotypes of letrozole-model of PCOS rats by modulating the NRF2/NFKB pathway. Life Sci. 2023;324:121737. [Content Brief]
- [3]. Legro R S, et al. Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome[J]. New England Journal of Medicine, 2007, 356(6): 551-566. [Content Brief]
- [4]. Jiann BP, et al. Effect of clomiphene on Ca(2+) movement in human prostate cancer cells. Life Sci. 2002;70(26):3167-3178. [Content Brief]
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