605685-94-7
605685-94-7
Chemical Structure
NSC 641396
- CAS No.: 605685-94-7
- Formula:C18H13NO3
- Molecular Weight:291.30
InChIKey: NJELFFLROCNKMT-UHFFFAOYSA-N
SMILES: O=C1C=CC(C2=C1C=CC3=C2N(C)C4=CC=C(OC)C=C34)=O
Biological Activity: NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. NSC 641396 is also a protein arginine N-methyltransferase 9 (PRMT9) inhibitor. NSC 641396 has antitumor activity[1][2].
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NSC 641396 | NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. NSC 641396 is also a protein arginine N-methyltransferase 9 (PRMT9) inhibitor. NSC 641396 has antitumor activity. | |||||||||||||||||||||
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References
- [1]. Tholander F, et al. Discovery of antimicrobial ribonucleotide reductase inhibitors by screening in microwell format. Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9798-803. [Content Brief]
- [2]. Dong H, et al. Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity. Nat Cancer. 2024 Apr;5(4):601-624. [Content Brief]
Keywords
